Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair

Repair of large segmental bone defects: BMP-2 gene activated muscle grafts vs. autologous bone grafting

BACKGROUND Common cell based strategies for the treatment of osseous defects require the isolation and expansion of autologous cells. Since this makes such approaches time-consuming and expensive, we developed a novel expedited technology creating gene activated muscle grafts. We have previously shown that large segmental bone defects in rats can be regenerated by implantation of muscle tissue ...

BMP-2 Gene & Cell-functionalized 3D Scaffolds for the Repair of Cranial Bone Defect

Various Dosages of BMP-2 for Management of Massive Bone Defect in Sprague Dawley Rat

Introduction: The use of BMP-2 plays an important role in the treatment of extensive bone defect. However, data about the optimal dosage of BMP-2 in the massive bone defect cases is rare. Material and Method: Twenty-five SD rats were randomly divided into a control group ofhydroxyapatite (HA) alone (Group I), HA+BMP-2 1µg/mL (Group II), HA+BMP-2 5 ug/mL (Group III), HA+BMP-2 10 µg/mL (Gro...

Feasibility study on repair for cranial defect of immaturity.

AIM To evaluate use of a titanium mesh to fill cranial defects in growing animals, as a model for juvenile humans. MATERIAL AND METHODS Thirty two-month-old Seghers pigs were evenly assigned to one of three groups: controls, a defect group (unrepaired 5 x 5 cm lesion), and a repair group (repaired 5 x 5 cm lesions). Histological evaluations and morphological measurements were conducted to com...

Reconstruction of cranial bone defects with BMP-2 releasing scaffolds

Kyung Shin Kang, Jin Woo Lee, Ki-Joo Kim, Jong-Won Rhie, and Dong-Woo Cho 4 Department of Mechanical Engineering, POSTECH, Pohang, Gyungbuk, 790-784, Korea Department of Nano Engineering, University of California, San Diego, CA, USA Department of Plastic Surgery, College of medicine, The Catholic University of Korea, Seoul, Korea Division of Integrative Biosciences and Biotechnology, POSTECH, P...